A family of toxins produced by a bacteria known as Clostridium botulinum. This toxin is one of the most lethal poisons known, interfering with the effect of the transmitter substance acethylcholine at the synapses (the contact point of a nerve ending with another nerve cell or a muscle) and leading to progressive paralysis of all muscles in the body, including the respiratory muscles.

In extremely low doses, botulinus toxin has been adopted in cases with localized muscle hyperactivity (lid spasms, torticollis, etc), resulting in a reduction in transmitting impulses to the muscle. Initial reports have been published regarding the use of botulinum toxin in hyperhidrosis.

Seems to work adequately in axillary hyperhidrosis
Last for 6-12 months depending on the dosage (0.5-1.0 Units/cm2)

Costly, treatment need to repeated at regular intervals
Treatment can be done only at clinic/by specialist
Potential side effects if dosages is not kept low
Could be painful as multiple injections are required on the skin surface